University of New Mexico, Biophysics Group, Department of Physics & Astronomy, Albuquerque, NM, USA.
IET Syst Biol. 2010 Nov;4(6):367-78. doi: 10.1049/iet-syb.2010.0007.
Certain short polycations, such as trans-activating transcriptional activator and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis. These cell-penetrating peptides can carry with them cargos of 30 amino acids, more than the nominal limit of 500 Da and enough to be therapeutic. An analysis of the electrostatics of a charge outside the cell membrane and some recent experiments suggest that transduction may proceed by molecular electroporation. Ways to target diseased cells, rather than all cells, are discussed.
某些短链多聚阳离子，如转录激活因子和聚精氨酸，通过一种称为转导的机制以及内吞作用和巨胞饮作用，迅速穿过哺乳动物细胞膜。这些细胞穿透肽可以携带 30 个氨基酸的有效载荷，超过 500 Da 的名义限制，足以达到治疗效果。对细胞膜外电荷的静电分析和最近的一些实验表明，转导可能通过分子电穿孔进行。还讨论了针对病变细胞而不是所有细胞的靶向方法。
