Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, CB # 7290, Chapel Hill, NC 27599, USA.
Future Microbiol. 2010 Oct;5(10):1581-97. doi: 10.2217/fmb.10.112.
Protein export is essential in all bacteria and many bacterial pathogens depend on specialized protein export systems for virulence. In Mycobacterium tuberculosis, the etiological agent of the disease tuberculosis, the conserved general secretion (Sec) and twin-arginine translocation (Tat) pathways perform the bulk of protein export and are both essential. M. tuberculosis also has specialized export pathways that transport specific subsets of proteins. One such pathway is the accessory SecA2 system, which is important for M. tuberculosis virulence. There are also specialized ESX export systems that function in virulence (ESX-1) or essential physiologic processes (ESX-3). The increasing prevalence of drug-resistant M. tuberculosis strains makes the development of novel drugs for tuberculosis an urgent priority. In this article, we discuss our current understanding of the protein export systems of M. tuberculosis and consider the potential of these pathways to be novel targets for tuberculosis drugs.
蛋白质的输出对于所有细菌来说都是至关重要的，许多细菌病原体依赖于专门的蛋白质输出系统来实现毒力。在结核分枝杆菌中，这种疾病的病原体，保守的通用分泌（Sec）和双精氨酸转运（Tat）途径执行大部分蛋白质输出，这两种途径都是必不可少的。结核分枝杆菌还具有专门的输出途径，用于运输特定的蛋白质亚群。其中一种途径是辅助 SecA2 系统，它对结核分枝杆菌的毒力很重要。还有专门的 ESX 输出系统在毒力（ESX-1）或基本生理过程（ESX-3）中发挥作用。越来越多的耐药结核分枝杆菌菌株的出现，使得开发新型结核病药物成为当务之急。在本文中，我们讨论了我们对结核分枝杆菌蛋白质输出系统的现有认识，并考虑了这些途径作为结核病药物新靶点的潜力。
