Université de Montréal, Département de biochimie, Montréal, Québec, Canada.
Curr Opin Microbiol. 2010 Feb;13(1):100-5. doi: 10.1016/j.mib.2009.12.003. Epub 2010 Jan 14.
The rise of resistance of pathogenic bacteria to antibiotics constitutes an increasing risk to public health. Environmental bacteria constitute a large reservoir of resistance determinants and it is predictable that resistance to more antibiotics will be acquired by even more pathogens in future. Innovative strategies are therefore needed to discover novel antibiotic targets as well as alternatives to classical antibiotics. This review will discuss recent advances toward the development of an alternative to classical antibiotics, antivirulence drugs targeting bacterial secretion systems that would disarm rather than kill bacteria. Important progress has been made especially targeting type III secretion systems that are used by many different Gram-negative pathogens. Antivirulence drugs that disarm bacterial pathogens have the potential to be an important alternative or addition to classical antibiotics in future.
病原菌对抗生素的耐药性不断上升，对公众健康构成的威胁日益严重。环境细菌是耐药决定因素的巨大储存库，预计未来甚至更多的病原体将获得更多抗生素的耐药性。因此，需要创新的策略来发现新的抗生素靶标以及替代经典抗生素的方法。这篇综述将讨论开发替代经典抗生素的最新进展，即针对细菌分泌系统的抗病毒药物，这些药物旨在削弱而不是杀死细菌。在靶向许多不同革兰氏阴性病原体使用的 III 型分泌系统方面已经取得了重要进展。在未来，削弱细菌病原体的抗病毒药物有可能成为经典抗生素的重要替代品或补充。
