Dash Sandip K
Apollo Hospital, Dhaka, Bangladesh.
Recent Pat CNS Drug Discov. 2011 Jan;6(1):65-76. doi: 10.2174/157488911794079073.
Alzheimer's disease is the most common form of dementia. Alzheimer's disease will be responsible for an enormous burden on the individual and the society, as with the aging of the population, the incidence and the prevalence will grow. Presently, the drugs used in Alzheimer's disease are only effective symptomatically and improve functioning. They do not halt the progression of the disease. With the recent advances in our understanding of the pathogenesis of this disease, there have been tremendous advances in the clinical trials of compounds that can modify the disease process. Numerous therapeutic interventions and neuroprotective approaches are also in trial phase. It seems that in near future some of these compounds may be found effective and safe for use in this disease there by reducing the incidence of this disease in years to come, thereby lessen the burden due to it. In this article various compounds that can modify the course of the disease are discussed. Some recent patents and inventions for the treatment of Alzheimer's disease have also been discussed.
阿尔茨海默病是最常见的痴呆形式。随着人口老龄化,阿尔茨海默病的发病率和患病率将会上升,这将给个人和社会带来巨大负担。目前,用于治疗阿尔茨海默病的药物仅能对症有效并改善功能,无法阻止疾病进展。随着我们对该疾病发病机制认识的最新进展,能够改变疾病进程的化合物的临床试验也取得了巨大进展。许多治疗干预措施和神经保护方法也处于试验阶段。在不久的将来,似乎这些化合物中的一些可能会被发现对治疗该疾病有效且安全,从而在未来几年降低该疾病的发病率,减轻由此带来的负担。本文讨论了各种能够改变疾病进程的化合物,还讨论了一些近期治疗阿尔茨海默病的专利和发明。