Department of Psychology, Stony Brook University, Stony Brook, New York, USA.
Psychophysiology. 2011 Jun;48(6):842-51. doi: 10.1111/j.1469-8986.2010.01149.x. Epub 2010 Nov 12.
Both exaggerated and attenuated responses to emotional stimuli have been documented in Generalized Anxiety Disorder (GAD). Event-related potentials are well-suited for examining the time-course of neural activity during emotional processing; early components (e.g., the P1) appear to index relatively automatic attention to emotional stimuli, whereas later positivities (e.g., the late positive potential or LPP) index dynamic allocation of attention to emotional stimuli. Twenty-one individuals with GAD and 25 healthy controls (HC) passively viewed emotional and neutral images while ERPs were recorded. An enhanced P1 for unpleasant compared to neutral images was larger in GAD. In addition, the increased LPP to unpleasant compared to neutral images was diminished in the GAD group. These data provide evidence for early hypervigilance for emotional stimuli, followed by failure to engage in elaborative processing, in GAD.
在广泛性焦虑障碍（GAD）中，已经记录到对情绪刺激的夸大和减弱反应。事件相关电位非常适合检查情绪处理过程中的神经活动时间进程；早期成分（例如，P1）似乎可以指示对情绪刺激的相对自动注意，而随后的正性（例如，晚正电位或 LPP）则指示对情绪刺激的注意力动态分配。21 名 GAD 患者和 25 名健康对照（HC）在被动观看情绪和中性图像时记录了 ERP。与中性图像相比，不愉快图像的 P1 增强在 GAD 中更大。此外，与中性图像相比，不愉快图像的 LPP 增加在 GAD 组中减少。这些数据为 GAD 中对情绪刺激的早期过度警惕，随后未能进行详尽处理提供了证据。
