Kakudo K, Miyauchi A, Ogihara T, Takai S I, Kitamura H, Kosaki G, Kumahara Y
Arch Pathol Lab Med. 1978 Sep;102(9):445-7.
This report presents a rare histological variation of medullary (C-cell) carcinoma of the thyroid, referred to as giant cell type, which is similar to that found in anaplastic carcinoma of the thyroid, or choriocarcinoma. The giant cells in this case possessed specific immunofluorescence for calcitonin and secretory granules in the cytoplasm. The giant cells were tumor cells of medullary carcinoma and could be distinguished from anaplastic carcinoma of the thyroid by various histological characteristics, such as nuclear invagination, an intermingled pattern of giant cells with typical small solid cells, infrequency of mitosis, and the existence of amyloid stroma.
本报告展示了甲状腺髓样（C细胞）癌一种罕见的组织学变异，称为巨细胞型，它类似于甲状腺未分化癌或绒毛膜癌中所见的情况。该病例中的巨细胞对降钙素具有特异性免疫荧光，且细胞质中有分泌颗粒。这些巨细胞是髓样癌的肿瘤细胞，可通过多种组织学特征与甲状腺未分化癌相区分，如核内陷、巨细胞与典型小实体细胞的混合模式、有丝分裂少见以及淀粉样间质的存在。
