Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, 6700-B Rockledge Drive, Room 55201, Bethesda, MD 20892, USA.
Vaccine. 2010 Dec 6;28(52):8229-35. doi: 10.1016/j.vaccine.2010.10.073. Epub 2010 Nov 10.
The search for an effective HIV vaccine continues to be a challenge. Several candidates have been tested in preclinical protocols, and a few have been tested in clinical trials without resounding success. It is unclear why vaccine approaches to control HIV infection have been unsuccessful, but opportunities to dissect the causes for the failure have surfaced from recent work on the virology, immunology and pathogenesis of HIV and from analysis of vaccine studies. The significance of the innate immune system in HIV infection may provide new paths to discover effective approaches. This report summarizes a workshop held to discuss the role of selected aspects of innate immunity to viral infections and successful vaccines that may have important implications for designing effective HIV vaccines.
寻找有效的 HIV 疫苗仍然是一个挑战。有几种候选疫苗已经在临床前方案中进行了测试，有几种已经在临床试验中进行了测试，但没有取得显著成功。目前尚不清楚为什么控制 HIV 感染的疫苗方法不成功，但最近对 HIV 的病毒学、免疫学和发病机制的研究以及对疫苗研究的分析，为剖析失败原因提供了机会。先天免疫系统在 HIV 感染中的重要性可能为发现有效方法提供新的途径。本报告总结了一次研讨会，讨论了病毒感染和成功疫苗的某些先天免疫方面的作用，这可能对设计有效的 HIV 疫苗具有重要意义。
