舒更葡糖钠：环糊精、选择性结合剂的研发、药理学、临床研发及未来方向

Sugammadex: cyclodextrins, development of selective binding agents, pharmacology, clinical development, and future directions.

作者信息

Akha Arezou Sadighi, Rosa Joseph, Jahr Jonathan S, Li Alvin, Kiai Kianusch

机构信息

UCLA JCCC Clinical Research Unit, 10945 Le Conte Avenue, 3360 PVUB, Los Angeles, CA 90095, USA.

出版信息

Anesthesiol Clin. 2010 Dec;28(4):691-708. doi: 10.1016/j.anclin.2010.08.014.

DOI:10.1016/j.anclin.2010.08.014

PMID:21074746

Abstract

Neuromuscular blocking agents are widely used in perioperative medicine to aid in endotracheal intubation, facilitate surgery, and in critical care/emergency medicine settings. Muscle relaxants have profound clinical uses in current surgical and intensive care and emergency medical therapy. This article reviews cyclodextrins, development of selective binding agents, clinical development, and future directions of sugammadex.

摘要

神经肌肉阻滞剂在围手术期医学中广泛应用，以辅助气管插管、便于手术操作，并用于重症监护/急诊医学环境。肌肉松弛剂在当前的外科手术、重症监护及急诊医疗治疗中具有重要的临床用途。本文综述了环糊精、选择性结合剂的研发、舒更葡糖钠的临床研发及未来发展方向。