Maimonides Medical Center, Department of Obstetrics and Gynecology, Genesis Fertility and Reproductive Medicine, Brooklyn, New York, USA.
Fertil Steril. 2011 Feb;95(2):747-50. doi: 10.1016/j.fertnstert.2010.10.011. Epub 2010 Nov 13.
To determine age-specific serum anti-Müllerian hormone (AMH) values for women presenting to U.S. fertility clinics.
Retrospective study.
Single clinical reference laboratory.
PATIENT(S): A total of 17,120 women of reproductive age ranging from 24 to 50 years old.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Determination of single-year median and mean AMH values with SDs.
RESULT(S): Single-year-specific median, mean, and SD values are summarized in Table 1. Both median and mean AMH values decreased steadily in a manner highly correlated with advancing age. The average yearly decrease in the median serum AMH value was 0.2 ng/mL/year through age 35 and then diminished to 0.1 ng/mL/year after age 35. The rate of decline in mean AMH values was 0.2 ng/mL/year through age 40 and then diminished to 0.1 ng/mL/year thereafter.
CONCLUSION(S): Median and mean AMH levels decreased steadily with increasing age from 24 to 50 years of age. Such data may be of value to physicians and their patients who are considering reproductive options.
确定就诊于美国生育诊所的女性的年龄特异性血清抗苗勒管激素（AMH）值。
回顾性研究。
单一临床参考实验室。
共 17120 名年龄在 24 至 50 岁之间的育龄妇女。
无。
确定具有标准差的单一年龄中位数和平均值 AMH 值。
表 1 总结了单一年龄特异性中位数、平均值和标准差。AMH 值的中位数和平均值均以与年龄增长高度相关的方式稳定下降。中位血清 AMH 值的平均每年下降 0.2ng/mL/年，在 35 岁之前，然后在 35 岁后降至 0.1ng/mL/年。平均 AMH 值的下降速度为 0.2ng/mL/年，直至 40 岁，之后每年下降 0.1ng/mL/年。
AMH 水平的中位数和平均值从 24 岁到 50 岁随年龄增长而稳定下降。这些数据可能对考虑生育选择的医生及其患者有价值。
