兰道-克莱夫纳综合征：罕见听觉处理障碍系列病例及文献综述
Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature.
作者信息
Fandiño Marcela, Connolly Mary, Usher Laurie, Palm Sheryl, Kozak Frederick K
机构信息
Division of Otolaryngology, Department of Surgery, University of British Columbia, Division of Pediatric Otolaryngology, BC Children's Hospital, Vancouver, British Columbia, Canada.
出版信息
Int J Pediatr Otorhinolaryngol. 2011 Jan;75(1):33-8. doi: 10.1016/j.ijporl.2010.10.001. Epub 2010 Nov 12.
OBJECTIVE
To describe the clinical presentation and treatment of 3 children with an Auditory Processing Disorder with an identifiable neurological cause: Landau-Kleffner syndrome. This classical syndrome is well recognized in pediatric neurology but the diagnosis is less well known to Pediatric Otolaryngology, Speech Language Pathology and Audiology services.
METHODS
Retrospective chart review of three patients with Landau-Kleffner syndrome.
RESULTS
In all cases, pharmacological intervention led to clinical and electroencephalographic improvement, but all patients had long-term difficulty with understanding sounds in a noisy environment. Magnetic Resonance Imaging (MRI) of the brain was normal in all three patients. Their language disturbance improved over time. Speech language intervention was helpful in addressing communication difficulties arising from the auditory processing/receptive and expressive language disorder.
CONCLUSION
A multidisciplinary assessment is the key for early diagnosis, treatment and follow-up in patients with this syndrome.
目的
描述3例患有听觉处理障碍且有明确神经学病因（兰道-克莱夫纳综合征）的儿童的临床表现及治疗情况。这种经典综合征在儿童神经学领域广为人知，但儿科耳鼻喉科、言语语言病理学和听力学服务部门对其诊断了解较少。
方法
对3例兰道-克莱夫纳综合征患者进行回顾性病历审查。
结果
在所有病例中，药物干预均使临床症状和脑电图得到改善，但所有患者在嘈杂环境中理解声音方面长期存在困难。3例患者的脑部磁共振成像（MRI）均正常。他们的语言障碍随时间推移有所改善。言语语言干预有助于解决因听觉处理/接受性和表达性语言障碍引起的沟通困难。
结论
多学科评估是该综合征患者早期诊断、治疗和随访的关键。
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