Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Stroke Cerebrovasc Dis. 2012 Jul;21(5):417-21. doi: 10.1016/j.jstrokecerebrovasdis.2010.09.008. Epub 2010 Nov 13.
Recurrent ischemic strokes often have uncommon causes in young adults. Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail.
反复发作的缺血性中风在年轻患者中常有不常见的病因。血管异常可被视为可能的病因。我们报告了一例 36 岁男性，尽管接受了药物治疗，但仍反复发作原因不明的缺血性中风。常规脑血管造影未发现异常。随后的脑组织活检显示出一种独特的组织病理学模式，表现为异常的血管周围胶原沉积，无炎症。反复发作的原因不明性中风可能有新的病因，当标准诊断检测失败时，应考虑进行脑活检。
