遗传性癌症综合征的小鼠模型。
Mouse models of inherited cancer syndromes.
机构信息
Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
出版信息
Hematol Oncol Clin North Am. 2010 Dec;24(6):1205-28. doi: 10.1016/j.hoc.2010.08.011.
Abstract
Animal models of cancer have been instrumental in understanding the progression and therapy of hereditary cancer syndromes. The ability to alter the genome of an individual mouse cell in both constitutive and inducible approaches has led to many novel insights into their human counterparts. In this review, knockout mouse models of inherited human cancer syndromes are presented and insights from the study of these models are highlighted.
摘要
癌症动物模型在理解遗传性癌症综合征的进展和治疗方面发挥了重要作用。通过组成性和诱导性方法改变单个小鼠细胞基因组的能力，为研究其人类对应物提供了许多新的见解。本文介绍了遗传性人类癌症综合征的基因敲除小鼠模型，并强调了这些模型研究的重要发现。
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