癌症的生物信息学和系统生物学。

Bioinformatics and systems biology of cancers.

机构信息

Department of Internal Medicine, School of Public Health, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.

出版信息

Prog Mol Biol Transl Sci. 2010;95:159-91. doi: 10.1016/B978-0-12-385071-3.00007-1.

DOI:10.1016/B978-0-12-385071-3.00007-1

PMID:21075332

Abstract

Molecular databases and bioinformatics methods and tools are essential for modern cancer research. Multilevel analyses of all the protein-coding genes, thousands of proteins, and hundreds of metabolites require integration in terms of signaling and metabolic pathways and networks. This chapter provides background and examples of genomic, gene expression, epigenomic, proteomic, and metabolomic investigations of cancer progression and emergence of invasive and metastatic properties of cancers.

摘要

分子数据库和生物信息学方法及工具是现代癌症研究的基础。所有编码蛋白基因、数千种蛋白和数百种代谢物的多层次分析需要整合到信号和代谢途径及网络中。本章提供了癌症进展以及癌症侵袭和转移特性出现的基因组、基因表达、表观基因组、蛋白质组和代谢组学研究的背景和实例。