Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA.
Fertil Steril. 2011 Mar 1;95(3):1119.e15-7. doi: 10.1016/j.fertnstert.2010.10.032.
To report a case of antenatally diagnosed congenital mesoblastic nephroma in an assisted reproductive technology (ART) conception.
Case report.
Tertiary care university-affiliated hospital.
PATIENT(S): Fetus of 26-weeks' gestation with antenatally diagnosed large abdominal tumor.
INTERVENTION(S): ART with transfer of cryopreserved embryo.
MAIN OUTCOME MEASURE(S): Postmortem examination.
RESULT(S): Examination revealed a congenital mesoblastic nephroma, mixed classic and cellular type, with marked intratumoral hemorrhage and associated hydrops. The marked fetal erythroblastosis was suggestive of fetal response to pronounced anemia. Intrauterine demise is attributed to fetal intratumoral hemorrhage and early nonimmune hydrops secondary to a large congenital mesoblastic nephroma.
CONCLUSION(S): This is the third reported case of congenital mesoblastic nephroma in an ART conception. Whether the association between mesoblastic nephroma and ART is coincidental or causative remains to be determined.
报告一例在辅助生殖技术（ART）受孕中产前诊断为先天性中胚层肾瘤的病例。
病例报告。
三级保健大学附属医院。
26 周妊娠胎儿，产前诊断为巨大腹部肿瘤。
ART 移植冷冻胚胎。
尸检结果。
检查显示为经典型和细胞型混合的先天性中胚层肾瘤，肿瘤内有明显出血，并伴有水肿。明显的胎儿成红细胞增多症提示胎儿对显著贫血的反应。宫内死亡归因于胎儿肿瘤内出血和早期非免疫性水肿，原因是巨大的先天性中胚层肾瘤。
这是第三例在 ART 受孕中报告的先天性中胚层肾瘤病例。中胚层肾瘤与 ART 之间的关联是偶然的还是因果关系尚待确定。
