惊恐障碍和创伤后应激障碍患者扣带回下回和脑干的差异活性。
Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD.
机构信息
Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, United States.
出版信息
J Anxiety Disord. 2011 Mar;25(2):251-7. doi: 10.1016/j.janxdis.2010.09.010. Epub 2010 Nov 13.
Abstract
Most functional neuroimaging studies of panic disorder (PD) have focused on the resting state, and have explored PD in relation to healthy controls rather than in relation to other anxiety disorders. Here, PD patients, posttraumatic stress disorder (PTSD) patients, and healthy control subjects were studied with functional magnetic resonance imaging utilizing an instructed fear conditioning paradigm incorporating both Threat and Safe conditions. Relative to PTSD and control subjects, PD patients demonstrated significantly less activation to the Threat condition and increased activity to the Safe condition in the subgenual cingulate, ventral striatum and extended amygdala, as well as in midbrain periaquaeductal grey, suggesting abnormal reactivity in this key region for fear expression. PTSD subjects failed to show the temporal pattern of activity decrease found in control subjects.
摘要
大多数惊恐障碍（PD）的功能性神经影像学研究都集中在静息状态，并且是在与健康对照组相关的情况下而不是与其他焦虑症相关的情况下研究 PD。在这里，使用包含威胁和安全条件的指令性恐惧条件反射范式，对 PD 患者、创伤后应激障碍（PTSD）患者和健康对照组进行了功能磁共振成像研究。与 PTSD 和对照组相比，PD 患者在威胁条件下的激活明显减少，在亚属扣带、腹侧纹状体和扩展杏仁核以及中脑导水管周围灰质中的活动增加，表明该恐惧表达的关键区域存在异常反应。PTSD 患者未能显示出对照组中发现的活动减少的时间模式。
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Behav Res Ther. 2009 Feb;47(2):111-8. doi: 10.1016/j.brat.2008.10.017. Epub 2008 Oct 29.
2
Neurobiology of panic disorder: from animal models to brain neuroimaging.惊恐障碍的神经生物学：从动物模型到脑成像
Neurosci Biobehav Rev. 2008 Sep;32(7):1326-35. doi: 10.1016/j.neubiorev.2008.05.017. Epub 2008 May 21.
3
Human fear-related motor neurocircuitry.人类与恐惧相关的运动神经回路。
Neuroscience. 2007 Nov 30;150(1):1-7. doi: 10.1016/j.neuroscience.2007.09.048. Epub 2007 Sep 26.
4
When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans.当恐惧临近时：威胁迫近会引发人类前额叶-导水管周围灰质的变化。
Science. 2007 Aug 24;317(5841):1079-83. doi: 10.1126/science.1144298.
5
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J Abnorm Psychol. 2007 Aug;116(3):612-7. doi: 10.1037/0021-843X.116.3.612.
6
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7
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8
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9
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10
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