Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, United States.
J Anxiety Disord. 2011 Mar;25(2):251-7. doi: 10.1016/j.janxdis.2010.09.010. Epub 2010 Nov 13.
Most functional neuroimaging studies of panic disorder (PD) have focused on the resting state, and have explored PD in relation to healthy controls rather than in relation to other anxiety disorders. Here, PD patients, posttraumatic stress disorder (PTSD) patients, and healthy control subjects were studied with functional magnetic resonance imaging utilizing an instructed fear conditioning paradigm incorporating both Threat and Safe conditions. Relative to PTSD and control subjects, PD patients demonstrated significantly less activation to the Threat condition and increased activity to the Safe condition in the subgenual cingulate, ventral striatum and extended amygdala, as well as in midbrain periaquaeductal grey, suggesting abnormal reactivity in this key region for fear expression. PTSD subjects failed to show the temporal pattern of activity decrease found in control subjects.
大多数惊恐障碍（PD）的功能性神经影像学研究都集中在静息状态，并且是在与健康对照组相关的情况下而不是与其他焦虑症相关的情况下研究 PD。在这里，使用包含威胁和安全条件的指令性恐惧条件反射范式，对 PD 患者、创伤后应激障碍（PTSD）患者和健康对照组进行了功能磁共振成像研究。与 PTSD 和对照组相比，PD 患者在威胁条件下的激活明显减少，在亚属扣带、腹侧纹状体和扩展杏仁核以及中脑导水管周围灰质中的活动增加，表明该恐惧表达的关键区域存在异常反应。PTSD 患者未能显示出对照组中发现的活动减少的时间模式。
