发现新型吲哚-2-甲酰胺类大麻素 CB(1)受体拮抗剂。
The discovery of novel indole-2-carboxamides as cannabinoid CB(1) receptor antagonists.
机构信息
Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK.
出版信息
Bioorg Med Chem Lett. 2011 Jan 1;21(1):497-501. doi: 10.1016/j.bmcl.2010.10.104. Epub 2010 Oct 26.
PMID:21075628
Abstract
The discovery and structure-activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 26i was found to be a high potency, selective cannabinoid CB(1) antagonist.
摘要
本发明公开了一类新型吲哚-2-甲酰胺类大麻素 CB(1)受体拮抗剂的发现和构效关系。研究发现化合物 26i 是一种高活性、选择性的大麻素 CB(1)受体拮抗剂。
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