Villar Emmanuel, Zaoui Philippe
Service de néphrologie, dialyse et transplantation rénale, centre hospitalier Lyon Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.
Nephrol Ther. 2010 Dec;6(7):585-90. doi: 10.1016/j.nephro.2010.08.002. Epub 2010 Nov 13.
In industrialized countries, renal epidemiology is faced with the growing epidemic of diabetes as cause of renal involvement or as an associated condition. In France, recent studies estimate that 400,000+ diabetics have a glomerular filtration rate lower than 60 mL/min/1.73 m², and that 7000+ are prevalent in dialysis. The vast majority has type 2 diabetes. In type 1 diabetes, renal prognosis improved over the last decade due to available aggressive glycemic control and treatment with renin-angiotensin system inhibitors. Diabetes has a negative impact on survival in end-stage renal disease, particularly for type 1 diabetes patients and for women with diabetes. In type 2 diabetes, improvement in early access to renal transplant could lead to improvement in outcomes, whereas they are usually contra-indicated for transplant because rapid decline in cardiovascular status on dialysis. All these epidemiological data help us to implement preventing measures and further researches in order to improve diabetes patient prognosis.
在工业化国家，肾脏流行病学面临着糖尿病作为肾脏受累原因或相关病症的日益流行。在法国，最近的研究估计，超过40万糖尿病患者的肾小球滤过率低于60 mL/分钟/1.73平方米，且7000多人正在接受透析治疗。绝大多数患者患有2型糖尿病。在1型糖尿病中，由于积极的血糖控制和肾素-血管紧张素系统抑制剂的应用，肾脏预后在过去十年有所改善。糖尿病对终末期肾病的生存有负面影响，尤其是对1型糖尿病患者和糖尿病女性患者。在2型糖尿病中，早期获得肾脏移植机会的改善可能会改善治疗结果，然而，由于透析时心血管状况迅速下降，2型糖尿病患者通常不适合进行移植。所有这些流行病学数据有助于我们实施预防措施和进一步研究，以改善糖尿病患者的预后。
