Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu 501-1194, Japan.
Jpn J Clin Oncol. 2011 Feb;41(2):225-31. doi: 10.1093/jjco/hyq185. Epub 2010 Nov 12.
To examine the association of smoking and lifestyle factors with pancreatic cancer death in the prospective design.
Mortality from pancreatic cancer in regard to smoking, body mass index, physical activity, and alcohol, coffee and green tea intake, was studied in a prospective cohort of 30,826 inhabitants in Takayama, Japan. In 1992, each subject completed a self-administered questionnaire on demographic information, smoking, drinking habits, diet, exercise and medical histories. The response rate was 85.3%.
From 1992 to 1999, 33 men and 19 women died due to pancreatic cancer. Hazard ratios and 95% confidence intervals were determined using Cox proportional hazards models. Women who were defined as current smokers at baseline had significant and increased risk of pancreatic cancer death after adjustment for age, body mass index and history of diabetes mellitus (Hazard ratio: 4.77, 95% confidence intervals: 1.58-14.4). There were significant positive associations of pancreatic cancer death with the years of smoking and the number of cigarettes consumed daily in women in a dose-dependent manner. Current smokers indicated a non-significant risk increase in men (Hazard ratio: 3.81, 95% confidence intervals: 0.88-16.6). Body mass index, physical activity, and alcohol, coffee and green tea intake were not significantly associated with pancreatic cancer death.
These data suggested that smoking increases the risk of death from pancreatic cancer in Japanese women.
在前瞻性设计中研究吸烟和生活方式因素与胰腺癌死亡的关联。
在日本高山的一个前瞻性队列中，研究了 30826 名居民的吸烟、体重指数、体力活动以及酒精、咖啡和绿茶摄入量与胰腺癌死亡率之间的关系。1992 年，每位受试者都完成了一份关于人口统计学信息、吸烟、饮酒习惯、饮食、运动和病史的自我报告式问卷。应答率为 85.3%。
1992 年至 1999 年期间，有 33 名男性和 19 名女性死于胰腺癌。使用 Cox 比例风险模型确定了风险比和 95%置信区间。基线时被定义为当前吸烟者的女性，在调整年龄、体重指数和糖尿病病史后，胰腺癌死亡的风险显著增加（风险比：4.77，95%置信区间：1.58-14.4）。女性中吸烟年限和每日吸烟量与胰腺癌死亡呈剂量依赖性的显著正相关。目前吸烟的男性胰腺癌死亡风险增加不显著（风险比：3.81，95%置信区间：0.88-16.6）。体重指数、体力活动以及酒精、咖啡和绿茶的摄入量与胰腺癌死亡无显著相关性。
这些数据表明，吸烟会增加日本女性死于胰腺癌的风险。
