Clarian Pathology Lab, Department of Pathology and Internal Medicine, Indiana University, Indianapolis, USA.
Mod Pathol. 2011 Feb;24(2):157-67. doi: 10.1038/modpathol.2010.200. Epub 2010 Nov 12.
Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for 'basal-like cancer', which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists.
乳腺癌是一种异质性疾病，包含多种具有不同形态特征和临床行为的实体。尽管形态学通常与乳腺癌中分子异常的模式相关，但也很明显，同一组织学类型的肿瘤表现出明显不同的临床行为。这在“基底样癌”中尤其如此，它是一种使用基因表达分析定义的实体。本文的目的是综述基底样乳腺癌的当前知识状态，讨论基底样和三阴性乳腺癌之间的关系，并阐明这些诊断对病理学家和肿瘤学家的实际意义。
