Manchester Interdisciplinary Biocentre (MIB), University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Chem Commun (Camb). 2010 Dec 28;46(48):9100-6. doi: 10.1039/c0cc03122d. Epub 2010 Nov 12.
Lactams are an important class of compounds owing to their presence in numerous biologically active molecules of natural and unnatural nature. They are also highly versatile intermediates that can be elaborated into interesting compounds for potential use in organic and medicinal chemistry endeavors. In this feature article, the reader will be given a background to olefin metathesis followed by concise discussions (with selected examples) to report recent applications of ring-closing metathesis to form lactams and macrolactams from acyclic diene precursors, an area which continues to deposit attractive applications in the chemical literature en route or in the final step to the target molecules.
内酰胺因其存在于天然和非天然的多种生物活性分子中而成为一类重要的化合物。它们也是非常多功能的中间体，可以被精心设计成具有潜在用途的有机和药物化学化合物。在这篇专题文章中，读者将了解烯烃复分解反应的背景，然后进行简洁的讨论（并附有精选示例），以报告最近将环 closing 复分解反应应用于从非环二烯前体形成内酰胺和大环内酯的应用，该领域在化学文献中继续为目标分子的路线或最终步骤提供有吸引力的应用。
