Seripa Davide, Paroni Giulia, Matera Maria G, Gravina Carolina, Scarcelli Carlo, Corritore Michele, D'Ambrosio Luigi P, Urbano Maria, D'Onofrio Grazia, Copetti Massimiliano, Kehoe Patrick G, Panza Francesco, Pilotto Alberto
Department of Medical Sciences, Geriatric Unit and Gerontology-Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, Foggia, Italy.
Age (Dordr). 2011 Sep;33(3):409-19. doi: 10.1007/s11357-010-9192-2. Epub 2010 Nov 13.
The association between angiotensin-converting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.
血管紧张素转换酶（ACE）基因分型与老年人功能衰退之间的关联仍存在争议。为评估ACE基因变异是否会影响老年人的功能能力，本研究探讨了常见的ACE插入/缺失（I/D）多态性与住院老年患者日常生活活动（ADL）所衡量的残疾之间的关联。我们分析了2128名住院老年患者群体中ACE基因分型（I/I、I/D和D/D）的频率，这些患者根据是否存在ADL残疾进行了分组。经对可能的混杂因素进行校正的逻辑回归分析，确定I/I基因型与ADL残疾之间存在关联（比值比=1.54，95%置信区间1.04 - 2.29）。这种关联在男性中显著（比值比=2.01，95%置信区间1.07 - 3.78），但在女性中不显著（比值比=1.36，95%置信区间0.82 - 2.25）。这些结果表明，ACE多态性可能作为住院老年患者ADL残疾的一种遗传标志物发挥作用。
