McAlister W H, McAlister V I, Kissane J M
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
AJNR Am J Neuroradiol. 1990 Mar-Apr;11(2):325-7.
Gadopentetate dimeglumine and a saline solution of similar osmolality of 2100 mOs/kg H2O were placed in the paws and in the thigh muscles and subcutaneous tissue of Sprague-Dawley rats weighing 225-250 g. The paws were serially photographed for 4 weeks and the thighs were examined histologically for up to 4 weeks. Gross and histologic reactions to gadopentetate dimeglumine were greater than those to the saline solution, and included tissue sloughs. When risk factors for extravascular extravasation are present, such as infusion sites in the dorsum of the hand or foot, or around the ankle, or when soft tissues are obscured by bandages, caution should be exercised when injecting gadopentetate dimeglumine.
将钆喷酸葡胺和渗透压相似（2100 mOs/kg H₂O）的盐溶液分别注入体重为225 - 250克的Sprague-Dawley大鼠的爪子、大腿肌肉和皮下组织。连续4周对爪子进行拍照，并对大腿进行长达4周的组织学检查。与盐溶液相比，钆喷酸葡胺引起的大体和组织学反应更强烈，包括组织脱落。当存在血管外渗漏的危险因素时，如在手背或脚背、脚踝周围的输液部位，或软组织被绷带遮盖时，注射钆喷酸葡胺时应谨慎。
