Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA.
Macromol Biosci. 2011 Feb 11;11(2):257-66. doi: 10.1002/mabi.201000313. Epub 2010 Nov 15.
The range of application of polyurethanes has been limited by their poor hemocompatibility and inability to resist non-specific binding of biomolecules and cells. In this work, a non-adhesive PU-based material was synthesized via the copolymerization of PU with dermatan sulfate. Incorporation of DS into the PU backbone dramatically increased material hydrophilicity and decreased protein adsorption. The in vitro adhesion of several cell types, including platelets, also significantly decreased with increasing DS content. Both the physical and biological properties of the DS contributed to the anti-adhesive properties of the PU/DS copolymer, and this anti-adhesive nature of PU/DS renders this new biomaterial attractive for blood-contacting or non-fouling applications.
聚氨脂的应用范围受到其较差的血液相容性和不能抵抗生物分子和细胞的非特异性结合的限制。在这项工作中，通过聚氨脂与硫酸皮肤素共聚合成了一种不粘连的聚氨脂基材料。DS 的加入极大地增加了材料的亲水性并减少了蛋白质的吸附。几种细胞类型（包括血小板）的体外黏附也随着 DS 含量的增加而显著降低。DS 的物理和生物学性质都有助于 PU/DS 共聚物的抗黏附性质，PU/DS 的这种抗黏附性质使这种新型生物材料在接触血液或不污染的应用中具有吸引力。
