Liu Runhui, Chen Xinyu, Gellman Samuel H, Masters Kristyn S
J Am Chem Soc. 2013 Nov 6;135(44):16296-9. doi: 10.1021/ja408634a.
Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomaterials-based approaches to tissue repair or regeneration. However, there are very few examples of synthetic materials that display selectivity in supporting cell growth. We describe nylon-3 polymers that support in vitro culture of endothelial cells but do not support the culture of smooth muscle cells or fibroblasts. These materials may be promising for vascular biomaterials applications.
能够选择性地促进特定细胞类型生长的底物对于复杂组织工程而言具有重要价值。一些细胞选择性肽已从细胞外基质蛋白中被鉴定出来；这些肽已被证明在基于生物材料的组织修复或再生方法中很有用。然而，在支持细胞生长方面具有选择性的合成材料实例却非常少。我们描述了一种尼龙-3聚合物，它能够支持内皮细胞的体外培养，但不支持平滑肌细胞或成纤维细胞的培养。这些材料在血管生物材料应用方面可能很有前景。
