Van den Hof M C, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, King's College School of Medicine, Denmark Hill, London, England.
Am J Obstet Gynecol. 1990 Mar;162(3):735-9. doi: 10.1016/0002-9378(90)90997-l.
A reference range for fetal platelet count with gestation was established from the study of samples obtained by cordocentesis from 229 pregnancies that had prenatal diagnosis. The mean platelet count increased from 187 +/- 47 x 10(9)/L at 15 weeks to 274 +/- 47 x 10(9)/L at 40 weeks' gestation. In 113 red cell-isoimmunized pregnancies, the moderately anemic fetuses were significantly thrombocythenic, whereas the severely anemic fetuses were thrombocytopenic. In 136 small-for-gestational-age fetuses the platelet count was reduced and there were significant correlations between the magnitude of the thrombocytopenia and the degree of fetal smallness, hypoxemia, and acidemia.
通过对229例接受产前诊断的妊娠病例经脐静脉穿刺获取的样本进行研究，建立了胎儿血小板计数随孕周变化的参考范围。血小板计数平均值从孕15周时的187±47×10⁹/L增加至孕40周时的274±47×10⁹/L。在113例红细胞同种免疫的妊娠病例中，中度贫血胎儿有明显血小板减少，而重度贫血胎儿则为血小板减少症。在136例小于胎龄儿中，血小板计数降低，且血小板减少的程度与胎儿生长受限程度、低氧血症及酸血症之间存在显著相关性。
