Shiga Katsuaki, Kodama Hiroko, Kaga Fumiaya, Izumi Youichi, Nakamoto Natsue, Fujisawa Chie
Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan.
Pediatr Int. 2011 Aug;53(4):501-4. doi: 10.1111/j.1442-200X.2010.03292.x.
A 4-year-old female patient was diagnosed with hypothyroidism caused by iodine deficiency. The patient's iodine levels in serum and urine were significantly low. The iodine concentration in the enteral formula was 1.6 µg/100 kcal as measured by inductively coupled plasma mass spectrometry. The patient's iodine intake while receiving the enteral formula was calculated to be 16 µg/day, which is much lower than the recommended dietary reference intake of 80 µg for children aged 3-5 years. The purpose of this study was to assess iodine concentrations in 20 enteral nutritional formulas available in Japan in order to assess whether low iodine concentration is a characteristic of one specific formula or whether it is a more prevalent problem.
Iodine concentrations in 20 popular nutritional formulas available in Japan, for which iodine content is not indicated in the ingredient list, were analyzed with inductively coupled plasma mass spectrometry.
Iodine concentrations were less than 5 µg/100 kcal and less than 10 µg/100 kcal in 13 and 18 enteral nutritional formulas, respectively.
Most of the enteral nutritional formulas analyzed had low iodine concentrations. These findings suggest that iodine deficiency is a likely outcome in patients who receive these formulas for a prolonged period.
一名4岁女性患者被诊断为碘缺乏所致的甲状腺功能减退症。患者血清和尿液中的碘水平显著偏低。通过电感耦合等离子体质谱法测定，肠内营养制剂中的碘浓度为1.6µg/100kcal。计算该患者接受肠内营养制剂时的碘摄入量为16µg/天，远低于3至5岁儿童80µg的膳食参考摄入量推荐值。本研究的目的是评估日本市面上20种肠内营养制剂中的碘浓度，以确定低碘浓度是某一特定制剂的特性，还是更为普遍的问题。
采用电感耦合等离子体质谱法分析了日本市面上20种常见的营养制剂中的碘浓度，这些制剂的成分列表中未标明碘含量。
13种和18种肠内营养制剂的碘浓度分别低于5µg/100kcal和10µg/100kcal。
所分析的大多数肠内营养制剂碘浓度较低。这些发现表明，长期接受这些制剂的患者可能会出现碘缺乏。
