Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, Houston, TX 77030, USA.
Brain Res Bull. 2011 Apr 25;85(1-2):14-20. doi: 10.1016/j.brainresbull.2010.11.002. Epub 2010 Nov 13.
Long-term memories are created when labile short-term memory traces are converted to more enduring forms. This process, called consolidation, is associated with changes in the synthesis of proteins that alter the biophysical properties of neurons and the strength of their synaptic connections. Recently, it has become clear that the consolidation process requires not only protein synthesis but also degradation. Here, we discuss recent findings on the roles of ubiquitination and protein degradation in synaptic plasticity and learning and memory.
长期记忆是由不稳定的短期记忆痕迹转化为更持久的形式而产生的。这个过程称为巩固，与蛋白质合成的变化有关，这些变化改变了神经元的生物物理特性和突触连接的强度。最近，人们已经清楚地认识到，巩固过程不仅需要蛋白质合成，还需要降解。在这里，我们讨论了泛素化和蛋白质降解在突触可塑性和学习记忆中的作用的最新发现。
