68Ga-枸橼酸盐 PET/CT 评估骨骼感染患者：初步结果。

68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results.

机构信息

Medicina Nucleare, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S Orsola-Malpighi, Bologna, Italy.

出版信息

J Nucl Med. 2010 Dec;51(12):1932-6. doi: 10.2967/jnumed.110.080184. Epub 2010 Nov 15.

DOI:10.2967/jnumed.110.080184

PMID:21078801

Abstract

UNLABELLED

The aim of this work was to preliminarily evaluate the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of (68)Ga-citrate PET/CT in a population of patients with suspected bone infections.

METHODS

We enrolled 31 patients with suspected osteomyelitis or diskitis who underwent a total of forty (68)Ga-citrate PET/CT scans. The results were compared with different combinations of diagnostic procedures (MRI, radiography, CT, or white blood cell scintigraphy), biopsy (when diagnostic), and follow-up data (at least 1 y) to determine the performance of (68)Ga-citrate PET/CT.

RESULTS

We found a sensitivity of 100%, a specificity of 76%, a positive predictive value of 85%, a negative predictive value of 100%, and an overall accuracy of 90%.

CONCLUSION

Although preliminary, these data confirm a possible role for (68)Ga-citrate in the diagnosis of bone infections, especially in consideration of its favorable characteristics.

摘要

目的本研究旨在初步评估（68）Ga-枸橼酸盐 PET/CT 在疑似骨感染患者中的灵敏度、特异性、阳性预测值、阴性预测值和总准确率。

方法我们纳入了 31 例疑似骨髓炎或椎间盘炎患者，共进行了 40 次（68）Ga-枸橼酸盐 PET/CT 扫描。将结果与不同的诊断程序（MRI、X 线摄影、CT 或白细胞闪烁扫描）、活检（当诊断为阳性时）以及随访数据（至少 1 年）进行比较，以确定（68）Ga-枸橼酸盐 PET/CT 的性能。

结果我们发现（68）Ga-枸橼酸盐 PET/CT 的灵敏度为 100%、特异性为 76%、阳性预测值为 85%、阴性预测值为 100%和总准确率为 90%。

结论尽管这是初步数据，但这些数据证实了（68）Ga-枸橼酸盐在诊断骨感染方面可能具有一定作用，尤其是考虑到其良好的特征。