Ralph R K, Wojcik S
Department of Cellular and Molecular Biology, University of Auckland, New Zealand.
Cancer Lett. 1990 Mar;49(3):181-5. doi: 10.1016/0304-3835(90)90156-r.
The effect of a variety of inhibitors of prostaglandin synthase, lipoxygenase and phospholipase on the growth of P815 murine mastocytoma cells was examined. Only lipoxygenase inhibitors substantially reduced growth, presumably by inhibiting the production of arachidonic acid metabolites rather than causing arachidonate accumulation since excess arachidonic acid did not reverse growth inhibition. Evidence is presented that production of leukotrienes B4, C4, D4 or E4 was not involved. Other metabolites of arachidonic acid were not excluded. A role for lipoxygenase in growth signal transduction in these and other cells is suggested.
研究了多种前列腺素合成酶、脂氧合酶和磷脂酶抑制剂对P815小鼠肥大细胞瘤细胞生长的影响。只有脂氧合酶抑制剂能显著降低细胞生长，这可能是通过抑制花生四烯酸代谢产物的产生，而不是导致花生四烯酸积累，因为过量的花生四烯酸并不能逆转生长抑制。有证据表明白三烯B4、C4、D4或E4的产生未参与其中。但不排除花生四烯酸的其他代谢产物。提示脂氧合酶在这些细胞和其他细胞的生长信号转导中发挥作用。
