Departmento de Recursos del Mar, Cinvestav del IPN, Km 6 Antigua Carretera a Progreso, Yucatán, C.P. 97310, Merida, Mexico.
Bull Environ Contam Toxicol. 2010 Dec;85(6):545-9. doi: 10.1007/s00128-010-0139-1. Epub 2010 Nov 17.
The goal of the present study was to evaluate the role of Tamoxifen (TAM), in the distribution and/or elimination kinetics of o,p'-DDT, in male tilapias. A non-compartmental analysis was chosen to describe the time course of o,p'-DDT plasma concentrations. Mean plasma concentration of o,p'-DDT following IP administration indicates a very complex kinetic profile. Tamoxifen decreased the o,p'-DDT mean half-life (t½) from 20.38 to 16.11 days, the Mean Residence Time (MRT) from 28.7 to 23.23 days, and clearance (CL) from 0.0031 to 0.001 mL/min. The distribution pattern of o,p'-DDT in tissues and the clearance in plasma suggest that storage points mediated through the membrane-receptor lipophilicity can be involved.
本研究旨在评估他莫昔芬（TAM）在雄性罗非鱼中 o,p'-DDT 的分布和/或消除动力学中的作用。选择非房室分析来描述 o,p'-DDT 血浆浓度的时间过程。IP 给药后 o,p'-DDT 的平均血浆浓度表明存在非常复杂的动力学特征。他莫昔芬将 o,p'-DDT 的平均半衰期（t1/2）从 20.38 天降至 16.11 天，平均驻留时间（MRT）从 28.7 天降至 23.23 天，清除率（CL）从 0.0031 降至 0.001 mL/min。o,p'-DDT 在组织中的分布模式和血浆中的清除率表明，通过膜受体亲脂性介导的储存点可能会涉及其中。
