Josefsson G, Gudmundsson G, Kolmert L, Wijkström S
Department of Orthopedic Surgery, Gävle Hospital, Sweden.
Clin Orthop Relat Res. 1990 Apr(253):173-8.
In Sweden in 1976, nine orthopedic departments organized a prospective, randomized, and controlled study in which the prophylactic effect of systemic antibiotics (SA) was compared to gentamicin bone cement (GBC) in 1688 consecutive total hip arthroplasties (THAs). After a follow-up period of one to two years, there was a statistically significant difference in the infection rate between the two groups in favor of the gentamicin cement. After five years or more, the difference was unaltered. Altogether, 16 deep infections had occurred in the SA group (1.9%) and seven (0.8%) in the GBC group. Roentgenographically, aseptic loosening had occurred in 29% and 24% of the hips in the SA and GBC groups, respectively, which suggests that admixture of the antibiotic did not weaken the cement. The results of this five-year review clearly showed the prophylactic value of gentamicin cement against deep infection after THA but did not support the hypothesis that this effect was prolonged over one year.
1976年在瑞典，九个骨科部门组织了一项前瞻性、随机对照研究，在1688例连续的全髋关节置换术（THA）中，比较了全身用抗生素（SA）与庆大霉素骨水泥（GBC）的预防效果。经过一到两年的随访期，两组的感染率存在统计学上的显著差异，庆大霉素骨水泥组更具优势。五年或更长时间后，这种差异没有改变。SA组共发生16例深部感染（1.9%），GBC组发生7例（0.8%）。X线检查显示，SA组和GBC组分别有29%和24%的髋关节出现无菌性松动，这表明抗生素的混合并未削弱骨水泥。这项为期五年的综述结果清楚地表明了庆大霉素骨水泥对THA术后深部感染的预防价值，但不支持这种效果会持续超过一年的假设。
