Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR 6101, France.
Eur J Immunol. 2010 Dec;40(12):3306-11. doi: 10.1002/eji.201040778.
The 3' regulatory region (3'RR) located downstream of the IgH gene is the master element that controls class switch recombination and sustains high-level transcription at the plasma-cell stage. This latter role suggests that the 3'RR may be involved in oncogene deregulation during the frequent IgH translocation events associated with B-cell malignancies. A convincing demonstration of the essential contribution of 3'RR in lymphomagenesis has been provided by transgenic animal models. The mouse 3'RR shares a strong structural homology with the regulatory regions located downstream of each human Cα gene. Mouse models exploring the role of the 3'RR in B-cell physiology and in malignancies should provide useful indications about the pathophysiology of human cell lymphocyte proliferation.
IgH 基因下游的 3' 调控区（3'RR）是控制类别转换重组和维持浆细胞阶段高水平转录的主要元件。后一作用表明，3'RR 可能参与与 B 细胞恶性肿瘤相关的频繁 IgH 易位事件中的癌基因失调。转基因动物模型提供了 3'RR 在淋巴瘤发生中的重要作用的令人信服的证明。小鼠 3'RR 与人类每个 Cα 基因下游的调控区具有很强的结构同源性。探索 3'RR 在 B 细胞生理和恶性肿瘤中的作用的小鼠模型应该为人类淋巴细胞增殖的病理生理学提供有用的指示。
