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免疫球蛋白重链（IgH）3'调控区与c-myc诱导的B细胞淋巴瘤发生

The IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesis.

作者信息

Ghazzaui Nour, Saintamand Alexis, Issaoui Hussein, Vincent-Fabert Christelle, Denizot Yves

机构信息

Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France.

出版信息

Oncotarget. 2017 Jan 24;8(4):7059-7067. doi: 10.18632/oncotarget.12535.

DOI:10.18632/oncotarget.12535
PMID:27729620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5351691/
Abstract

Deregulation and mutations of c-myc have been reported in multiple mature B-cell malignancies such as Burkitt lymphoma, myeloma and plasma cell lymphoma. After translocation into the immunoglobulin heavy chain (IgH) locus, c-myc is constitutively expressed under the control of active IgH cis-regulatory enhancers. Those located in the IgH 3' regulatory region (3'RR) are master control elements of transcription. Over the past decade numerous convincing demonstrations of 3'RR's contribution to mature c-myc-induced lymphomagenesis have been made using transgenic models with various types of IgH-c-myc translocations and transgenes. This review highlights how IgH 3'RR physiological functions play a critical role in c-myc deregulation during lymphomagenesis.

摘要

在多种成熟B细胞恶性肿瘤如伯基特淋巴瘤、骨髓瘤和浆细胞淋巴瘤中，已报道c-myc存在失调和突变。c-myc易位至免疫球蛋白重链（IgH）基因座后，在活跃的IgH顺式调控增强子的控制下持续表达。位于IgH 3'调控区（3'RR）的增强子是转录的主控元件。在过去十年中，使用具有各种类型IgH-c-myc易位和转基因的转基因模型，对3'RR在成熟c-myc诱导的淋巴瘤发生中的作用进行了大量令人信服的论证。本综述重点介绍了IgH 3'RR的生理功能在淋巴瘤发生过程中c-myc失调中如何发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d2/5351691/bdf1758d857d/oncotarget-08-7059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d2/5351691/6fab26c64c6d/oncotarget-08-7059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d2/5351691/bdf1758d857d/oncotarget-08-7059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d2/5351691/6fab26c64c6d/oncotarget-08-7059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d2/5351691/bdf1758d857d/oncotarget-08-7059-g002.jpg

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KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.卡波西肉瘤相关疱疹病毒（KSHV）编码的病毒白细胞介素-6（vIL-6）与失调的c-Myc协同作用，驱动小鼠发生浆母细胞性肿瘤。
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Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.
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Cancers (Basel). 2021 Jun 29;13(13):3270. doi: 10.3390/cancers13133270.
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The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies.Eµ-hnRNP K 小鼠淋巴瘤模型：hnRNP K 在 B 细胞恶性肿瘤中作用的新见解。
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