Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia.
Int J Cancer. 2011 Oct 1;129(7):1678-88. doi: 10.1002/ijc.25769. Epub 2011 Feb 11.
Previous studies suggest that exposure to pesticides increases the risk of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether professional pest treatments in or around the home before birth or during childhood increased the risk of childhood ALL. Data from 388 cases and 870 frequency-matched controls were analyzed using unconditional logistic regression, adjusting for study matching variables and potential confounders, to calculate odds ratios (ORs). A meta-analysis of our findings with the published findings of previous studies was also conducted. The ORs for any professional pest control treatments were 1.19 (95% CI 0.83, 1.69) in the year before pregnancy, 1.30 (95% CI 0.86, 1.97) during pregnancy and 1.24 (95% CI 0.93, 1.65) for those done after the child's birth. The ORs for exposure after birth were highest when it occurred between the ages of two and three years. ORs were elevated for termite treatments before birth. ORs were higher for pre-B than T cell ALL and for t(12;21) (ETV6-Runx-1) than other cytogenetic sub-types. The pooled OR from a meta-analysis of our study with three previous studies of professional pest control treatments during pregnancy was 1.37 (95% CI 1.00, 1.88). Our results, and those of our meta-analysis, provide some evidence of a modestly increased risk of ALL for professional pest control treatments done during the index pregnancy and possibly in the child's early years. The analysis of pooled data from international collaborations may provide more certainty regarding these potentially important associations.
先前的研究表明，接触农药会增加儿童急性淋巴细胞白血病（ALL）的风险。本分析旨在研究在胎儿期或儿童期进行的家庭内外专业虫害防治是否会增加儿童 ALL 的风险。使用非条件逻辑回归分析了 388 例病例和 870 例频数匹配对照的数据，调整了研究匹配变量和潜在混杂因素，以计算比值比（OR）。还对我们的发现与先前研究的已发表结果进行了荟萃分析。在怀孕前一年进行任何专业虫害防治的 OR 为 1.19（95%CI 0.83,1.69），怀孕期间为 1.30（95%CI 0.86,1.97），在孩子出生后为 1.24（95%CI 0.93,1.65）。出生后接触的 OR 在 2 至 3 岁时最高。在出生前进行白蚁防治的 OR 升高。与 T 细胞 ALL 相比，前 B 细胞 ALL 的 OR 更高，与其他细胞遗传学亚型相比，t（12;21）（ETV6-Runx-1）的 OR 更高。荟萃分析纳入了本研究和另外三项关于孕期专业虫害防治的研究，结果显示 OR 为 1.37（95%CI 1.00,1.88）。我们的结果和荟萃分析的结果都提供了一些证据，表明在指数妊娠期间和儿童早期进行的专业虫害防治可能会略微增加 ALL 的风险。来自国际合作的汇总数据分析可能会为这些潜在重要关联提供更大的确定性。
