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Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
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Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.
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Bortezomib (Velcadetrade mark) in the Treatment of Multiple Myeloma.
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Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.
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Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.
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XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
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Bypassing a kinase activity with an ATP-competitive drug.
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