Medical Research Council (MRC) Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
Sci Signal. 2010 Nov 16;3(148):pe43. doi: 10.1126/scisignal.3148pe43.
Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.
内吞作用调节了一类被称为卷曲蛋白（Fz）的受体成员的活性，这些受体控制经典的β-连环蛋白信号和平面细胞极性途径；然而，尚不清楚是什么决定了激活哪条途径。现在有证据表明，鸟嘌呤核苷酸三磷酸酶 Rab5 是内吞作用的关键调节因子，它直接与 Fz 蛋白结合，随后的运输步骤决定了 Fz 信号的结果。
