通过失败序列的聚合对合成寡脱氧核苷酸进行纯化。
Synthetic oligodeoxynucleotide purification by polymerization of failure sequences.
机构信息
Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA.
出版信息
Chem Commun (Camb). 2011 Jan 28;47(4):1345-7. doi: 10.1039/c0cc04374e. Epub 2010 Nov 17.
PMID:21082113
Abstract
Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramidite followed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drug purification.
摘要
合成寡脱氧核苷酸通过带有丙烯酰胺基的磷酰胺进行加帽失败序列的纯化，然后进行聚合和产物提取。该方法适用于大规模寡核苷酸药物的纯化。
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