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Predictable difficulty or difficulty to predict.可预测的困难或难以预测的困难。
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2
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本文引用的文献

1
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.人 ATP 结合盒转运蛋白核苷酸结合域中的功能热点。
Protein Sci. 2010 Nov;19(11):2110-21. doi: 10.1002/pro.491.
2
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.鉴定出一种尿酸转运蛋白ABCG2，其具有导致痛风的常见功能多态性。
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. doi: 10.1073/pnas.0901249106. Epub 2009 Jun 8.
3
Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing.ABCB11基因中的错义突变和单核苷酸多态性会损害胆盐输出泵的加工和功能，或破坏信使前体RNA剪接。
Hepatology. 2009 Feb;49(2):553-67. doi: 10.1002/hep.22683.
4
Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.三磷酸腺苷结合盒转运体C亚家族成员3非同义单核苷酸多态性的功能分析
Pharmacogenet Genomics. 2008 Sep;18(9):823-33. doi: 10.1097/FPC.0b013e328306e9ae.
5
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.人类多药耐药蛋白4（MRP4，ABCC4）：一个高度多态性基因的功能分析
J Pharmacol Exp Ther. 2008 Jun;325(3):859-68. doi: 10.1124/jpet.108.136523. Epub 2008 Mar 25.
6
Substrate-dependent effects of human ABCB1 coding polymorphisms.人类ABCB1编码多态性的底物依赖性效应。
J Pharmacol Exp Ther. 2008 May;325(2):435-42. doi: 10.1124/jpet.107.135194. Epub 2008 Feb 20.
7
ABCC6 mutations in pseudoxanthoma elasticum: an update including eight novel ones.弹性假黄瘤中的ABCC6突变：最新进展，包括八个新突变
Mol Vis. 2008 Jan 24;14:118-24.
8
Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump.在胆盐输出泵存在1331T>C多态性的携带者中，对妊娠期肝内胆汁淤积症和避孕药引起的胆汁淤积症易感性增加。
World J Gastroenterol. 2008 Jan 7;14(1):38-45. doi: 10.3748/wjg.14.38.
9
Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.胆汁盐输出泵（Bsep/Abcb11）的进行性和良性突变中的质膜表达水平与胆汁淤积性疾病的严重程度相关。
Am J Physiol Cell Physiol. 2007 Nov;293(5):C1709-16. doi: 10.1152/ajpcell.00327.2007. Epub 2007 Sep 13.
10
Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).定量构效关系分析和分子动力学模拟以功能验证人类ABC转运蛋白ABCB1（P-糖蛋白/多药耐药蛋白1）的非同义多态性
Biochemistry. 2007 Jul 3;46(26):7678-93. doi: 10.1021/bi700330b. Epub 2007 Jun 9.

Predictable difficulty or difficulty to predict.

作者信息

Arányi Tamás, Fülöp Krisztina, Symmons Orsolya, Pomozi Viola, Váradi András

出版信息

Protein Sci. 2011 Jan;20(1):1-3; author reply 4-5. doi: 10.1002/pro.552.

DOI:10.1002/pro.552
PMID:21082744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3047055/
Abstract
摘要