Shrivastav Pranav S, Buha Shailesh M, Sanyal Mallika
Chemistry Department, School of Sciences, Gujarat University, Navrangpura, Ahmedabad-380009.
Bioanalysis. 2010 Feb;2(2):263-76. doi: 10.4155/bio.09.184.
β-blockers are a class of antihypertensive drugs that are used for the management of cardiac arrhythmias, cardioprotection after myocardial infarction (heart attack) and hypertension. They have revolutionized the medical management of angina pectoris and are recommended as first-line agents by national and international guidelines. Although β-blockers are still the cornerstone for the treatment of heart failure, some of the drugs in this category are prohibited in several sports requiring vehicle control and bodily movements as they reduce heart rate and tremors, and improve performance. As a result, urine analysis of β-blockers is mandatory in doping control and toxicological screening. The determination of plasma levels of β-blockers helps to ensure noncompliance in patients with persistent hypertonia to confirm the diagnosis of β-blocker poisoning and for therapeutic drug monitoring. This review provides a comprehensive account of various analytical methods developed for detection and quantitation of β-blockers in plasma and urine.
β受体阻滞剂是一类抗高血压药物，用于治疗心律失常、心肌梗死（心脏病发作）后的心脏保护和高血压。它们彻底改变了心绞痛的药物治疗方法，并被国家和国际指南推荐为一线药物。尽管β受体阻滞剂仍是治疗心力衰竭的基石，但这类药物中的一些在一些需要车辆控制和身体运动的运动项目中被禁止使用，因为它们会降低心率和震颤，并提高运动表现。因此，在兴奋剂检测和毒理学筛查中，对β受体阻滞剂进行尿液分析是强制性的。测定血浆中β受体阻滞剂的水平有助于确保持续性高血压患者不遵医嘱，以确认β受体阻滞剂中毒的诊断并进行治疗药物监测。本综述全面介绍了为检测和定量血浆及尿液中的β受体阻滞剂而开发的各种分析方法。
