Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Expert Rev Hematol. 2009 Apr;2(2):197-208. doi: 10.1586/ehm.09.9.
Umbilical cord blood transplantation is becoming an acceptable alternative source of hematopoietic stem cells for patients with malignant diseases. Cord blood differs from bone marrow and peripheral blood progenitors in its immune tolerance and kinetics of engraftment. In this article, we will review the biology of cord blood stem cells and clinical studies of cord blood transplants in pediatric and adult populations. We will also discuss potential uses of cord blood stem cells in regenerative medicine and novel methods for ex vivo expansion of hematopoietic stem cells. As we learn more about cord blood transplants, there is the potential to overcome the limitations of cord blood transplants so that they can become more widely available.
脐带血移植正成为恶性疾病患者造血干细胞的一种可接受的替代来源。脐带血在免疫耐受和植入动力学方面与骨髓和外周血祖细胞不同。本文将综述脐带血干细胞的生物学特性和脐带血移植在儿科和成人患者中的临床研究。我们还将讨论脐带血干细胞在再生医学中的潜在用途和体外扩增造血干细胞的新方法。随着我们对脐带血移植的了解不断深入，有可能克服脐带血移植的局限性，使其得到更广泛的应用。
