3G11 在 CD4+T 细胞介导的自身免疫和免疫耐受中的表达。
3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance.
机构信息
Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, USA.
出版信息
Int Immunopharmacol. 2011 May;11(5):593-6. doi: 10.1016/j.intimp.2010.11.005. Epub 2010 Nov 24.
Abstract
3G11 is a sialylated carbohydrate epitope of the disialoganglioside molecule expressed on mouse CD4(+) T cells. Recent research showed that 3G11 expression is related to the modulation of T cell function, i.e., 3G11(-) T cells exhibit anergic/Treg characteristics and efficiently inhibit autoimmunity in the central nervous system. The relationship between 3G11 expression and immune tolerance is summarized in this literature review.
摘要
3G11 是表达在小鼠 CD4(+) T 细胞上的二唾液酸神经节苷脂分子的唾液酸化碳水化合物表位。最近的研究表明，3G11 的表达与 T 细胞功能的调节有关，即 3G11(-)T 细胞表现出无能/Treg 特征，并有效地抑制中枢神经系统中的自身免疫。本文综述了 3G11 表达与免疫耐受之间的关系。
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