Division of Nephrology and Endocrinology, Department of Medicine, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Endocrinology. 2011 Jan;152(1):4-10. doi: 10.1210/en.2010-0800. Epub 2010 Nov 17.
Fibroblast growth factor 23 (FGF23) was identified in 2000. Since then, FGF23 has been found to physiologically regulate phosphate metabolism and aberrant actions of FGF23 results in several disorders of phosphate and bone metabolism. In addition, FGF23 plays an important role in the development of chronic kidney disease-mineral and bone disorder. However, further investigations are necessary, especially with regard to the regulation of FGF23 expression. In this minireview, we focus on the physiological and pathophysiological significance of FGF23 in phosphate and bone metabolism.
成纤维细胞生长因子 23（FGF23）于 2000 年被发现。自此，人们发现 FGF23 可在生理上调节磷酸盐代谢，而 FGF23 的异常作用会导致几种磷酸盐和骨代谢紊乱。此外，FGF23 在慢性肾脏病-矿物质和骨异常的发生发展中起着重要作用。然而，仍需要进一步的研究，特别是关于 FGF23 表达的调控。在这篇简评中，我们重点关注 FGF23 在磷酸盐和骨代谢中的生理和病理生理学意义。
