Honda Shinji, Yoshimura Mitsuhiro, Ohno Keiichi, Yamamoto Eiji, Kitada Noriaki, Hashida Tohru, Imagawa Fuminori
Dept. of Pharmacy, Kyoto City Hospital.
Gan To Kagaku Ryoho. 2010 Nov;37(11):2101-4.
Fifty-six patients treated with oxaliplatin were examined in order to clarify the factors that influence the appearance of allergic reactions by oxaliplatin at Kyoto City Hospital between January 2009 and December 2009, retrospectively. The number of patients in allergic and non-allergic group was 10 and 46, respectively. Patients' characteristics, the presence of hepatic metastasis, hepatic failure and kidney failure, albumin and white blood cell counts were compared in both groups. In the allergic group, the rate of hepatic metastasis was significantly higher than that in the non-allergic group (p=0.011). In conclusion, hepatic metastasis was suggested to be a factor that causes allergic reactions after administration of oxaliplatin.
