Inoue D, Shirayama T, Omori I, Sakai R, Tatsumi T, Miyazaki H, Asayama J, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine.
Kokyu To Junkan. 1990 Feb;38(2):173-7.
Using conventional glass microelectrode technique, electrophysiological effects of flecainide acetate on guinea-pig left atrial muscle fibers were examined. Resting membrane potential was not affected by flecainide at any concentrations tested (10(-7) M-3 X 10(-5) M), although overshoot potential was significantly decreased at the concentration over 3 X 10(-6) M. Effective refractory period significantly increased at 10(-5) M. The reduction of Vmax was about 25% and 50% by 3 X 10(-6) M and 10(-5) M, respectively at 1 Hz. At 3 X 10(-6) M, Vmax decreased by about 10%, 15%, 22%, 33%, and 34% at 0.2, 0.5, 1, 2, and 3 Hz respectively. Flecainide, decreased Vmax of atrial muscle fibers in a dose and frequency dependent manner. It is suggested that flecainide might be effective in the treatment of atrial tachyarrhythmias.
采用传统玻璃微电极技术，研究了醋酸氟卡尼对豚鼠左心房肌纤维的电生理效应。在所测试的任何浓度（10⁻⁷ M - 3×10⁻⁵ M）下，静息膜电位均不受氟卡尼影响，尽管在浓度超过3×10⁻⁶ M时超射电位显著降低。在10⁻⁵ M时有效不应期显著延长。在1 Hz时，3×10⁻⁶ M和10⁻⁵ M的氟卡尼分别使Vmax降低约25%和50%。在3×10⁻⁶ M时，在0.2、0.5、1、2和3 Hz时Vmax分别降低约10%、15%、22%、33%和34%。氟卡尼以剂量和频率依赖性方式降低心房肌纤维的Vmax。提示氟卡尼可能对治疗房性快速性心律失常有效。
