Takemura Masashi, Morimura Keiichirou, Yoshida Kayo, Fujiwara Yushi
Dept. of Upper Gastrointestinal Surgery, Hyogo College of Medicine.
Gan To Kagaku Ryoho. 2010 Nov;37(11):2143-6.
We reported herein four resected cases with basaloid carcinoma of the esophagus and measured the activity of 5-FU related enzymes (TS, DPD, OPRT) in cancer tissue. These activities compared with those in squamous cell carcinoma. Only one case was diagnosed as basaloid carcinoma by preoperative biopsy specimen at endoscopic examination. The esophagectomy was performed thoracoscopically in all cases, and the abdominal procedure was done with the laparoscopic approach in two cases. Anastomotic leakage occurred in one case. No case had lymph node metastasis. On the other hand, a lymphatic invasion was detected in one case, and venous invasion in two, respectively. Two cases had mediastinal lymph node recurrence. DPD activity and OPRT activity showed no difference between squamous cell carcinoma and basaloid carcinoma. On the other hand, the TS activity was significantly higher in basaloid carcinoma. From the standpoint of 5-FU-related enzyme activities, basaloid carcinoma possibly has more resistance to 5-FU than squamous cell carcinoma.
我们在此报告4例食管基底样癌切除病例，并测定了癌组织中与5-氟尿嘧啶（5-FU）相关的酶（胸苷合成酶[TS]、二氢嘧啶脱氢酶[DPD]、乳清苷磷酸核糖转移酶[OPRT]）的活性。将这些活性与鳞状细胞癌中的活性进行比较。在内镜检查时，仅1例术前活检标本被诊断为基底样癌。所有病例均采用胸腔镜进行食管切除术，2例采用腹腔镜进行腹部手术。1例发生吻合口漏。无病例发生淋巴结转移。另一方面，分别有1例检测到淋巴管浸润，2例检测到静脉浸润。2例发生纵隔淋巴结复发。DPD活性和OPRT活性在鳞状细胞癌和基底样癌之间无差异。另一方面，基底样癌中的TS活性显著更高。从与5-FU相关的酶活性角度来看，基底样癌可能比鳞状细胞癌对5-FU具有更强的耐药性。
