Chawla Sanjeev, Zhang Yu, Wang Sumei, Chaudhary Sangeeta, Chou Chou, O'Rourke Donald M, Vossough Arastoo, Melhem Elias R, Poptani Harish
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Comput Assist Tomogr. 2010 Nov-Dec;34(6):836-41. doi: 10.1097/RCT.0b013e3181ec554e.
To differentiate glioblastomas, primary cerebral lymphomas (PCLs), and brain metastases using multivoxel proton magnetic resonance (MR) spectroscopic imaging.
A total of 56 patients with brain neoplasms underwent MR imaging and proton MR spectroscopic imaging. The data were analyzed from contrast-enhancing and peritumoral regions (PTR). N-acetylaspartate/creatine (Cr), choline (Cho)/Cr, glutamate+glutamine/Cr, myo-inositol/Cr, and lipids+lactate/Cr ratios were computed, and pairwise comparisons between neoplasms were made using Mann-Whitney U tests.
The PTR demonstrated most significant differences in metabolite ratios. The Cho/Cr ratio in glioblastomas (0.46 [0.01]) was significantly higher than that in metastases (0.38 [0.02], P = 0.01). Significantly elevated Cho/Cr levels were also noted in PCLs (0.48 [0.03]) compared with those in metastases (P = 0.04). In addition, PCLs also demonstrated significantly higher lipids+lactate/Cr levels (11.83 [2.59]) compared with glioblastomas (4.50 [0.59], P = 0.003) and metastases (2.79 [0.33], P = 0.001).
Proton MR spectroscopic imaging from PTR may assist in the differentiation of glioblastomas, metastases, and PCLs.
利用多体素质子磁共振（MR）波谱成像鉴别胶质母细胞瘤、原发性脑淋巴瘤（PCL）和脑转移瘤。
共有56例脑肿瘤患者接受了MR成像和质子MR波谱成像检查。对增强区域和瘤周区域（PTR）的数据进行分析。计算N-乙酰天门冬氨酸/肌酸（Cr）、胆碱（Cho）/Cr、谷氨酸+谷氨酰胺/Cr、肌醇/Cr以及脂质+乳酸/Cr的比值，并使用曼-惠特尼U检验对肿瘤之间进行两两比较。
PTR在代谢物比值方面显示出最显著的差异。胶质母细胞瘤的Cho/Cr比值（0.46 [0.01]）显著高于转移瘤（0.38 [0.02]，P = 0.01）。与转移瘤相比，PCL中的Cho/Cr水平也显著升高（0.48 [0.03]，P = 0.04）。此外，与胶质母细胞瘤（4.50 [0.59]，P = 0.003）和转移瘤（2.79 [0.33]，P = 0.001）相比，PCL的脂质+乳酸/Cr水平也显著更高（11.83 [2.59]）。
来自PTR的质子MR波谱成像可能有助于鉴别胶质母细胞瘤、转移瘤和PCL。
