García-Macías M C, Abad M, Alonso M J, Flores T, Bullón A
Department of Pathology, University of Salamanca School of Medicine, Spain.
Acta Cytol. 1990 Mar-Apr;34(2):175-8.
Masson's vegetant hemangioendothelioma is a benign intravascular tumor, sometimes confused with such malignant vascular tumors as angiosarcoma, whose clinical appearance is nonspecific and whose diagnosis can only be established through microscopic examination. The fine needle aspiration (FNA) cytologic findings together with the histologic and immunohistochemical findings of such a tumor in a 22-year-old man are presented. Cytologically, the material obtained by FNA consisted of two distinct populations of cells. One type of cell had large nuclei (sometimes displaced towards the periphery), finely granular chromatin, prominent nucleoli and abundant globular cytoplasm. The second type of cell had spindle-shaped or oval nuclei, granular chromatin and scanty eosinophilic cytoplasm. Although these findings may permit the cytologic recognition of this entity, the aspirate in this case was interpreted as showing a vascular mesenchymal tumor of probable malignancy. Histologic examination of the excised tumor, aided by immunoperoxidase studies for factor VIII antigen that revealed the endothelial nature of the proliferating cells, established the correct diagnosis.
马松增殖性血管内皮瘤是一种良性血管内肿瘤，有时会与血管肉瘤等恶性血管肿瘤相混淆，其临床表现不具特异性，只能通过显微镜检查来确诊。本文呈现了一名22岁男性患者该肿瘤的细针穿刺（FNA）细胞学检查结果，以及组织学和免疫组化检查结果。在细胞学上，FNA获取的材料由两种不同类型的细胞组成。一种细胞具有大细胞核（有时核向周边移位）、细颗粒状染色质、明显的核仁以及丰富的球状细胞质。第二种细胞具有梭形或椭圆形细胞核、颗粒状染色质以及少量嗜酸性细胞质。尽管这些发现可能有助于从细胞学上识别该实体，但该病例的穿刺物被解释为显示出一种可能为恶性的血管间叶性肿瘤。切除肿瘤的组织学检查，借助针对因子VIII抗原的免疫过氧化物酶研究揭示了增殖细胞的内皮性质，从而确立了正确的诊断。
