Department of Operative Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.
J Appl Oral Sci. 2010 Sep-Oct;18(5):533-7. doi: 10.1590/s1678-77572010000500018.
Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC.
Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation.
Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia.
The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects.
光化性唇炎（AC）是一种由紫外线长期照射引起的唇红部癌前病变。本研究旨在评估 3%双氯芬酸在 2.5%透明质酸凝胶治疗 AC 中的疗效。
34 例慢性 AC 患者每天两次接受局部双氯芬酸治疗，持续 30 至 180 天。通过临床检查和数字摄影记录，每 15 天对患者进行随访。
27 例完成研究的患者中，12 例（44%）的白色斑块和脱屑区域完全消退，15 例（56%）的唇炎临床图片部分消退。后者组接受了白色斑块区域的切除术，其诊断为从轻度到中度上皮不典型增生不等。
结果表明双氯芬酸在透明质酸凝胶治疗 AC 中具有良好的应用前景。这种治疗方法具有非侵入性和副作用少的优点。
