Hospital de Clínicas de Porto Alegre, RS, Brasil.
Braz J Med Biol Res. 2011 Jan;44(1):78-83. doi: 10.1590/s0100-879x2010007500122. Epub 2010 Nov 12.
The aim of the present study was to assess the prevalence of osteoporosis in a sample of 32 patients with spontaneous primary ovarian insufficiency (POI) in comparison to reference groups of 25 pre- and 55 postmenopausal women. Hip (lumbar) and spinal bone mineral density (BMD) measurements were performed by dual-energy X-ray absorptiometry in the three groups. The median age of POI patients at the time of diagnosis was 35 years (interquartile range: 27-37 years). The mean ± SD age of postmenopausal reference women (52.16 ± 3.65 years) was higher than that of POI (46.28 ± 10.38 years) and premenopausal women (43.96 ± 7.08; P = 0.001) at the time of BMD measurement. Twenty-seven (84.4%) POI women were receiving hormone replacement therapy (HRT) at the time of the study. In the postmenopausal reference group, 30.4% were current users of HRT. Lumbar BMD was significantly lower in the POI group (1.050 ± 0.17 g/cm²) compared to the age-matched premenopausal reference group (1.136 ± 0.12 g/cm²; P = 0.040). Moreover, 22 (68.7%) POI women had low bone density (osteopenia/osteoporosis by World Health Organization criteria) versus 47.3% of the postmenopausal reference group (P = 0.042). In conclusion, the present data indicate that BMD is significantly lower in patients with POI than in age-matched premenopausal women. Also, the prevalence of osteopenia/osteoporosis is higher in POI women than in women after natural menopause. Early medical interventions are necessary to ensure that women with POI will maintain their bonemass.
本研究的目的是评估 32 例自发性卵巢功能不全（POI）患者与 25 例绝经前和 55 例绝经后妇女参考组的骨质疏松症患病率。在三组中通过双能 X 射线吸收法进行髋部（腰椎）和脊柱骨矿物质密度（BMD）测量。POI 患者诊断时的中位年龄为 35 岁（四分位间距：27-37 岁）。绝经后参考组女性（52.16 ± 3.65 岁）的平均年龄高于 POI 组（46.28 ± 10.38 岁）和绝经前女性（43.96 ± 7.08 岁；P = 0.001）在 BMD 测量时。27 例（84.4%）POI 女性在研究时正在接受激素替代治疗（HRT）。在绝经后参考组中，30.4%是 HRT 的当前使用者。与年龄匹配的绝经前参考组（1.136 ± 0.12 g/cm²；P = 0.040）相比，POI 组的腰椎 BMD 显著降低（1.050 ± 0.17 g/cm²）。此外，22 例（68.7%）POI 女性有低骨密度（根据世界卫生组织标准为骨质疏松症/骨质疏松症），而绝经后参考组为 47.3%（P = 0.042）。总之，目前的数据表明 POI 患者的 BMD 明显低于年龄匹配的绝经前女性。此外，POI 女性的骨质疏松症/骨质疏松症患病率高于自然绝经后女性。早期的医疗干预措施是必要的，以确保 POI 妇女能够保持她们的骨量。
