[遭受电击的大鼠大脑中钠钾ATP酶及中间代谢酶的活性]
[Activity of Na, K-ATPase and the enzymes of intermediate metabolism in the brains of rats exposed to electroshock].
作者信息
Golenda A M, Kryzhanovskiĭ G N, Lutsenko V K, Sakharova O P, Glebov R N
出版信息
Biull Eksp Biol Med. 1978 Aug;86(8):139-42.
Activity of Na, K -ATPase, acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) in the fractions of the rat brain and spinal cord tissue were studied in rats during a single electroshock (ES) and 5 and 30 minutes after it. GAD activity of the synaptosome fraction was shown to decrease insignificantly, but activity of AChE, Na, K -ATPase and possibly of proteolytic enzymes increased 5 minutes after electroshock and became normal in 30 minutes. It is supposed that the revealed inhibition of Na, K -ATPase activity in the "synaptosomes" of the rat brain cortex could be of pathogenetic significance in the origination of the convulsive process.
研究了大鼠单次电击（ES）期间及电击后5分钟和30分钟时，大鼠脑和脊髓组织各部分中钠钾 -ATP酶、乙酰胆碱酯酶（AChE）和谷氨酸脱羧酶（GAD）的活性。结果显示，突触体部分的GAD活性略有下降，但电击后5分钟时AChE、钠钾 -ATP酶以及可能的蛋白水解酶的活性增加，30分钟后恢复正常。据推测，大鼠大脑皮层“突触体”中钠钾 -ATP酶活性的这种抑制作用可能在惊厥过程的发生中具有致病意义。
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